ABSTRACT

A sustained release system for Metoprolol succinate designed to increase its residence time in the stomach without contact with the tablets was achieved through the preparation of floating tablets by the direct compression method. Using different grades polymers like HPMC K100M and HPMC K4M were used to retain the drug release and to form the floating tablets. The drug retained in the floating tablets decreased with increase in concentration of polymer content. All floating tablets formulations showed good flow properties. The FTIR shows there is no interaction between drug and polymers. Floating ability in 0.1 N HCl simulated gastric fluid without pepsin was also tested. The formulation F9 containing HPMC K100M and HPMC K4M shows maximum drug release was found.

Key words: Metaprolol Succinate, Floating tablets, HPMC, Carbomer, Sustained release.

ABSTRACT

The aim of present work was to show the effect of various super disintegrates on the disintegration time and in vitro drug release rate. In this study, an attempt has been made to prepare rapid disintegrating tablets of the drug using different super disintegrants following wet granulation method. The Tablets were formulated by direct compression method, using Mannitol as diluent. Crospovidone (XL-PVP), croscarmellose sodium (Ac-Di-Sol®), Sodium starch glycolate were used as super disintegrants at different concentrations. The Precompression parameters like bulk density, tapped density, Carr’s Index and angle of repose were determined. The post compression parameters like the hardness, thickness, friability, weight variation, Disintegration time, in-vitro dissolution, FT-IR studies were carried out to check whether any interaction had occurred, results were promising. The optimized formulation was selected based on the results and stability studies were carried out on the optimized formulation and the percentage drug release was found to be 97.8%.

Key words: Mouth dissolving tablets, Ramipril, Mannitol, Super disintegrants, mouth dissolving tablets.

ABSTRACT

The objective of review article is oral disintegrating films are alternative dosage forms to tablets, capsules and syrups for pediatric and geriatric patients who experience difficulties swallowing traditional oral solid-dosage forms. Oral dissolving film technology (ODFT) that can be administered in the buccal cavity for a short period of time in secs and gives better therapeutic action. ODFT offers an alternate platform for molecules undergoes first pass metabolism. ODFs are a proven and accepted technology for the systemic delivery of APIs for over-the-counter (OTC) medications and are in the early- to mid-development stages for prescription drugs. So, various pharma companies adopted advance technologies to make ODFT commercialized in large scale despite of several limitations.

Key words: Fast dissolving films, Solvent casting, Semisolid casting, Hot melt extrusion, Solid dispersion extrusion, Rolling Method, Solu Strip.

ABSTRACT

Erythrina variegata a member of the Fabaceae family, have used in traditional medicine as nervine sedative, febrifuge, anti-asthmatic, antiepileptic and antiulcer. The purpose of the present study is to investigate the acute oral toxicity and antiulcer activity of the ethanol extract of Erythrina variegata (EEEV) extract in albino rats. Study on acute toxicity of extract found to be safe at the doses 2000mg/kg body weight orally as per OECD guidelines No.423. PMP at the doses of 200 and 400 mg/kg body weight orally was administered to evaluate anti-ulcer activity by using pyloric ligation (PL), and cold-restraint stress induced gastric ulcer models in Albino rats. Ethanol extract of Erythrina variegata (EEEV) dose dependent inhibition in pyloric ligation (PL), and cold-restraint stress induced gastric lesions in rats. All the results are found to be statistically significant (p≤0.01). Hence we suggest that ethanol extract of Erythrina variegata (EEEV) possess antiulcer effect that may be due to cytoprotective mechanism. These results support the ethnomedical uses of the plant in the treatment of gastric ulcer.

Keywords: Erythrina variegata, Antiulcer, Pyloric Ligation (PL), Cold-restraint stress.

ABSTRACT

Mucoadhesive drug delivery system is delivery system which utilized the property of the polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for extended period of time. Bio adhesion is an interfacial phenomenon in which to materials, at least one of which is biological, are held together with the interfacial forces. The attachment could be between an artificial material and biological substrate, such adhesion between polymer and a biological membrane. In case of polymer attached to the mucin layer of a mucosal tissue, the term mucoadhesion is used. The mucosal layer lines a number of regions of the body including the gastro intestinal tract, the urogenitial tract, the airways, the ear, nose and eye. These represent potentials sites for attachment of any bio adhesive system and hence, the mucoadhesive drug delivery system includes buccal, oral, rectal, nasal and ocular delivery systems.

Keywords: Bio adhesive dug delivery system (BADDS), Mucin, Bio adhesion, Mucoadhesion.

ABSTRACT

Inhaled Insulin is a recent therapeutic advance for the treatment of Diabetes. It offers a convenient, as well as accepted, alternative to injected Insulin. Subcutaneous administration of Insulin results in the pain, inconvenience, and disruption of lifestyle associated with the injection of Insulin, so there has been increasing demand in the development of Aerosolized Insulin. Recent studies shown that Aerosolized Insulin is effectively delivered to the alveolar region of the lung, absorption and glucose levels rates are shown similar to those achieved with SC delivered Insulin. Aerosolized Insulin is well-tolerated and avoids changes in pulmonary function. Due to some limitations in Aerosolized inhalation, there are novel drug delivery systems of different formulations of Insulin, which are under development, to improve the efficiency of Insulin to deliver into the systemic circulation. Among them Techno sphere Insulin Inhaler offers a viable therapeutic option for the treatment of Diabetes.

Key words: Technosphere, Insulin, Diabetes Mellitus, Fumaryl Diketopiperazine, Glycosylated hemoglobin (A1C).

ABSTRACT

Cancer known medically as a malignant neoplasm, is a broad group of various diseases, all involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invade nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous. Benign tumors do not grow uncontrollably, do not invade neighboring tissues, and do not spread throughout the body. There are over 200 different known cancers that afflict humans. The present review discussed on types, signs & symptoms and treatment of cancer.

Key words: Cancer, Types, Signs & Symptoms, Treatment.