ABSTRACT Cancer-induced anemia is most common in patients with cancer and in patients undergoing chemotherapy and radiation therapy. The severity of anemia depends on the extent of disease and the density of treatment. Repeated cycles of chemotherapy may impair erythropoiesis synthesis that results in decrease functional capacity and quality of life. In cancer patients, the incidence of anemia may rise 40%.According to European cancer anemia survey (ECAS) 53% of patients did not receive any treatment for their anemia.Anemia has also been identified as an adverse prognostic factor for these patients.thus Anemia exerts a negative influence on the quality of life of cancer patients as it may contribute to cancer-induced fatigue. This article reviews the current available scientific literature regarding the effect of FERA-Q tablets to support the treatment of Cancer induced Anaemia in patients. Key words: FERA-Q tablets, Cancer induced Anaemia.

ABSTRACT The present study focuses on the preliminary phytochemical profile of bark and root of P. roxburghii. The preliminary phytochemical screening showed the presence of Alkaloids, Flavonoids, Carbohydrates, Glycosides, Steroids, Phenols, Proteins, Amino acids, Tannis, Saponins, Terpenoids, Coumarins and fixed oil. Key words: Putranjiva roxburghii Wall., Phytochemical profile, Plant extracts, Euphorbiaceae and Chhattisgarh.

The phytochemical analysis of methanolic extract of Ctenolepis garcinii (Burm. f.) C.B. Clarke was studied in the present study. The methanolic extract was screened using UV-Vis spectroscopy, HPLC and FTIR by standard procedure. The UV-Visible spectrum showed the compounds separated at the nm of 200, 250, 331, 398, 433, 450, 500, 550, 606, 659, 700, 750, 862, 909, 975, 996, 1053 and 1100 with the absorption 4.000, 0.384, 1.342, 1.207, 4.000, 4,000, 4,000, 2.960, 3.612, 0.424, 0.954, 0.331, 0.130, 0.127, 0.111, 0.104, 0.043 and 0.003 respectively. The qualitative HPLC fingerprint profile displayed eight compounds at different retention times. The profile displayed four compounds at different retention times of 1.867min, 2.063min, 2.797min and 3.000min. The profile displayed six prominent peaks at the retention time of 1.963min, 2.107min, 2.283min, 2.647min, 2.793min, 3.000min, followed by two moderate peaks were also observed at the retention time of 3.240min and 3.413min. The result of FTIR analysis was found the presence of functional groups such as ethers, alcohols, solfonic acids, solfonic acids, aliphatic ethers, vinyl ethers, isopropyl group, benzophenones, aldehydes, phosphines, aliphatic compounds, carboxylic acids, aromatic amines, primary amines and amides. Key words: Ctenolepis garcinii, Methanolic extract, UV-Visible, HPLC, FTIR.

In this article, the study of never technology of capsule in solid dosage form among all in pharmaceutical dosage forms. This review includes newer trends related to capsule shell, capsule fill material, capsule sealing technique and different capsule systems to achieve modified drug release, encapsulation of various kind of materials and for modified application like mapping of the drug for clinical evaluation Either this done by capsule shell or by dosage filling in capsule dosage forms. This article mostly focuses on advancement of capsule in capsule technology. In this the study is about to reduce the frequency of dosing or to increase effectiveness of the drug by localization at the site of action, reducing the dose required, or providing uniform drug delivery. Capsugel: capsule filling liquid capsule technology offers a proven ability of new line extensions and is suitable for nutraceutical and pharmaceutical applications. The capsule capsule technology represents an advance of our first liquid filled the hard capsule technology. Key words: Cap in cap technology, Capsugel, Capsule, Hard gelatin capsule, Duocap.

Montelukast Sodium is a leukotriene receptor antagonist (LTRA) used in maintenance treatment of asthma and to relieve symptoms of seasonal allergies. Montelukast Sodium has oral bioavailability of 64% due to hepatic first pass metabolism and has a short half-life of 5.5 hr. The present work was an attempt to develop and evaluate melt-in mouth sublingual tablets of Montelukast Sodium which can reduce the frequency of dosing and improve bioavailability. These melt-in mouth sublingual tablets were prepared by direct compression methods. These melt-in mouth sublingual tablets were prepared by direct compression methods. The IR and DSC studies show no interaction between drug and polymer or with other additives. Satisfactory results were obtained when subjected to quality control tests of the prepared tablets were done. The stability studies conducted for a period of 6 months showed no appreciable change in drug content. Tablet containing Crospovidone: Ac-Di-Sol (3:1) showed optimum performance against all other prepared formulations. The mean relative bioavailability of the chosen Montelukast Sodium tablet compared to the commercial product (Kokast) was 154.8%. the melt-in mouth sublingual tablet of Montelukast Sodium with improved bioavailability was established. Key words: Montelukast Sodium - melt-in mouth sublingual tablets (MMST) - Crospovidone:Ac-Di-Sol.

Two sensitive, precise, accurate and simple methods has been developed and validated for the analysis of Atenolol, in combination with Hydrochlorothiazide and Losartan potassium in tablet dasage form. Method A involved chromatographic estimation of Atenolol in combination with Hydrochlorothiazide and Losartan potassium in tablet dasage form by RP-HPLC. Chromatographic resolution was achieved on a reverse-phase Zorbax SB-C18 (150 x 4.6 mm), 3.5μm column using acetonitrile: water: 0.05mM sodium dihydrogen ortho phosphate (pH 2.5) in the ratio of (40:10:50) as mobile phase with a flow rate of 0.7mL/min and isocratic elution with a total run time of 8 minutes. The retention time of Atenolol, Hydrochlorothiazide, Losartan potassium was found to be 1.921, 2.630 and 5.061 respectively. Detection of the multi compounds was carried out at 210nm. The peaks of atenlol, hydrochlorothiazide and losartan potassium were well separated . The Calibration curves were linear over studies ranges with correlation co-efficient found between the range of 0.99 to 1.00. The proposed method is accurate with 99.8% recovery for atenolol, 100.9% recovery for hydrochlorothiazide and 99.6% recovery for losartan potassium and precise (% RSD < 0.5). Key words: Atenolol, Hydrochlorothiazide, Losartan potassium, HPLC..

A simple, precise, rapid, specific and accurate method has been made for the estimation of Sultiam in formulation by RP – HPLC method taking water and methanol in the ratio 85:15. Standard substance was dissolved in Methanol was scanned and the spectra was recorded and the spectrum shows that λmax of Sultiam was 245 nm. Reverse phase chromatographic technique was selected by using Hypersil ODS 250 x 4.6mm, 5μm column as a stationary phase with different compositions of water and methanol was selected as mobile phase for the analysis. 245 nm was selected as detection wavelength. The calibration curve was plotted using concentration against peak area. With the optimized chromatographic conditions, the drug was linear in the concentration range of 2.5 - 15 μg/ ml. the correlation coefficient was found to be 0.998. By using this method, the main peak of Sultiam was eluted at 7.13 minutes. In this method the optical parameters like Correlation coefficient, Slope, Intercept, LOD and LOQ were calculated. Key words: Methanol, Correlation coefficient RP-HPLC, Calibration curve, Sultian.